{
  "cells": [
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "%matplotlib inline"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "\npynet metastasis tumor segmentation\n===================================\n\nCredit: A Grigis\n\npynet is a Python package related to deep learning and its application in\nMRI mediacal data analysis. It is accessible to everybody, and is reusable\nin various contexts. The project is hosted on github:\nhttps://github.com/neurospin/pynet.\n\nIn this notebook we will learn how to segment tumors using MRI images from the\nBrats dataset. The NvNet proposed by Andriy Myronenko's will be trained. This\nnetwork is a combination of a Vnet (3d Unet) and a VAE (variation\nauto-encoder).\n\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "import os\nimport sys\nif \"CI_MODE\" in os.environ:\n    sys.exit()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "Inspect the NvNet network\n--------------------------\n\nInspect some layers of the network.\n\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "from pprint import pprint\nimport pynet.models as models\nfrom pynet import NetParameters\nfrom pynet.utils import get_named_layers\nfrom pynet.utils import setup_logging\n# from pynet.plotting.network import plot_net_rescue\n\nsetup_logging(level=\"info\")\n\nmodel = models.NvNet(\n    input_shape=(128, 128, 128),\n    in_channels=1,\n    num_classes=4,\n    activation=\"relu\",\n    normalization=\"group_normalization\",\n    mode=\"trilinear\",\n    with_vae=True)\nlayers = get_named_layers(model)\npprint(layers)\n# graph_file = plot_net_rescue(model, (1, 1, 128, 128, 128))"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "Import the brats dataset\n------------------------\n\nUse the fetcher of the pynet package.\n\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "from pynet.datasets import DataManager, fetch_brats\nfrom pynet.plotting import plot_data\n\ndata = fetch_brats(\n    datasetdir=\"/neurospin/nsap/datasets/brats\")\nmanager = DataManager(\n    input_path=data.input_path,\n    metadata_path=data.metadata_path,\n    output_path=data.output_path,\n    projection_labels=None,\n    number_of_folds=10,\n    batch_size=1,\n    stratify_label=\"grade\",\n    # input_transforms=[\n    #     RandomFlipDimensions(ndims=3, proba=0.5, with_channels=True),\n    #     Offset(nb_channels=4, factor=0.1)],\n    sampler=\"random\",\n    add_input=True,\n    test_size=0.1,\n    pin_memory=True)\ndataset = manager[\"test\"][:1]\nprint(dataset.inputs.shape, dataset.outputs.shape)\nplot_data(dataset.inputs, channel=1, nb_samples=5)\nplot_data(dataset.outputs, channel=1, nb_samples=5)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "Training\n--------\n\nFrom the available models load the 3D NvNet, and start the training.\n\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "import os\nfrom torch.optim import lr_scheduler\nimport pynet\nfrom pynet.losses import NvNetCombinedLoss\nfrom pynet.interfaces import NvNetSegmenter\nfrom pynet.plotting import plot_history\nfrom pynet.history import History\n\nlosses = pynet.get_tools(tool_name=\"losses\")\nmy_loss = losses[\"NvNetCombinedLoss\"](\n    num_classes=4,\n    k1=0.1,\n    k2=0.1)\noutdir = \"/neurospin/nsap/tmp/nvnet\"\nif not os.path.isdir(outdir):\n    os.mkdir(outdir)\ntrained_model = os.path.join(outdir, \"model_0_epoch_99.pth\")\nnvnet_params = NetParameters(\n    input_shape=(150, 190, 135),\n    in_channels=4,\n    num_classes=4,\n    activation=\"relu\",\n    normalization=\"group_normalization\",\n    mode=\"trilinear\",\n    with_vae=True)\n\nif os.path.isfile(trained_model):\n    nvnet = NvNetSegmenter(\n        nvnet_params,\n        optimizer_name=\"Adam\",\n        learning_rate=1e-4,\n        weight_decay=1e-5,\n        loss=my_loss,\n        pretrained=trained_model,\n        use_cuda=True)\n    train_history = History.load(\n        os.path.join(outdir, \"train_0_epoch_9.pkl\"))\n    valid_history = History.load(\n        os.path.join(outdir, \"validation_0_epoch_9.pkl\"))\nelse:\n    nvnet = NvNetSegmenter(\n        nvnet_params,\n        optimizer_name=\"Adam\",\n        learning_rate=1e-4,\n        weight_decay=1e-5,\n        loss=my_loss,\n        use_cuda=True)\n    scheduler = lr_scheduler.ReduceLROnPlateau(\n        optimizer=nvnet.optimizer,\n        mode=\"min\",\n        factor=0.5,\n        patience=5)\n    train_history, valid_history = nvnet.training(\n        manager=manager,\n        nb_epochs=100,\n        checkpointdir=outdir,\n        # fold_index=0,\n        scheduler=scheduler,\n        with_validation=True)\nprint(train_history)\nprint(valid_history)\nplot_history(train_history)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "Testing\n-------\n\nFinaly use the testing set and check the results.\n\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "collapsed": false
      },
      "outputs": [],
      "source": [
        "y_pred, X, y_true, loss, values = nvnet.testing(\n    manager=manager,\n    with_logit=False,\n    predict=False)\nprint(y_pred.shape, X.shape, y_true.shape)\n# y_pred = np.expand_dims(y_pred, axis=1)\n# data = np.concatenate((y_pred, y_true, X), axis=1)\n# plot_data(data, nb_samples=5)\n\nif \"CI_MODE\" not in os.environ:\n    import matplotlib.pyplot as plt\n    plt.show()"
      ]
    }
  ],
  "metadata": {
    "kernelspec": {
      "display_name": "Python 3",
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    "language_info": {
      "codemirror_mode": {
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      "file_extension": ".py",
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